Asthma Home > Xolair Warnings and Precautions

Some Xolair warnings and precautions to be aware of include the possibility of Xolair making your asthma symptoms worse, the safety of using the drug when pregnant or breastfeeding, and risk of severe allergic reactions in some people who take Xolair. Among the people who should not take Xolair are those who are allergic to the drug or its inactive ingredients.

Xolair: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Xolair® (omalizumab) if you have:
  • Plans to travel to an area with a high risk for parasitic infections
  • Any allergies, including allergies to food, dyes, or preservatives.


Also let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Xolair Warnings and Precautions

Some warnings and precautions to be aware of with Xolair include:
  • Xolair can cause severe allergic reactions in some people. These allergic reactions can occur with the first or any subsequent Xolair doses. Your healthcare provider may want to watch you for a while after each injection.
  • In previous clinical studies, Xolair increased the risk of cancer. Up to 0.5 percent of people taking Xolair developed cancer, compared to 0.2 percent of those not taking Xolair.
  • You should not stop or decrease any of your other asthma medications when you first start Xolair unless your healthcare provider instructs you otherwise.
  • Xolair is not a fast-acting asthma medication and cannot replace fast-acting rescue inhalers. Everyone taking Xolair should also have a rescue asthma medication available at all times. Let your healthcare provider know if you need to use your rescue inhaler more frequently than usual, as this may be a sign that your asthma is getting worse.
  • Xolair can immediately make your asthma symptoms worse. If this happens, use your rescue inhaler (such as albuterol) as needed and contact your healthcare provider for further instruction.
  • One study in Brazil suggested that people taking Xolair have a higher risk of parasitic infections. Talk with your healthcare provider if you live in (or will be traveling to) areas that have a higher risk of parasites.
  • Xolair is considered a pregnancy Category B medication. This means that Xolair is probably safe to use during pregnancy -- though the full risks are not known. Talk with your healthcare provider about the risks and benefits of using Xolair during pregnancy (see Xolair and Pregnancy for more information).
  • It is not known if Xolair passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Xolair (see Xolair and Breastfeeding for more information).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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