Zyflo is a prescription drug that is used for the prevention of asthma attacks in both adults and children. The medication is effective at controlling asthma symptoms and preventing asthma attacks from occurring. Zyflo comes in tablet form and is generally taken four times a day. Among the factors that can affect the dosage your healthcare provider prescribes are other medical conditions you may have and other medications you may be taking.

In February 2008, the manufacturer of Zyflo announced that it has discontinued making this product. The manufacturer stated that since the longer-acting version, Zyflo CR, became available in 2007, use of immediate-release Zyflo declined significantly. Zyflo CR will still be available.

What Is Zyflo?

Zyflo® (zileuton) is a prescription medication used to prevent asthma attacks in adults and children as young as 12 years old.
(Click Zyflo Uses for more information on what it is used for, including possible off-label uses of the medication.)

Who Makes Zyflo?

The medication is made by Critical Therapeutics, Inc.

How Does It Work?

Zyflo is part of a group of medications called leukotriene synthesis inhibitors. Leukotrienes are chemicals produced by the body in response to allergens or other problems. In the lungs, leukotrienes cause swelling and inflammation in the airways and constriction of the muscles of the respiratory tract.
This medication works by preventing the body from making leukotrienes, preventing these leukotriene chemicals from causing asthma symptoms.


In studies of Zyflo for asthma, people taking it had improved breathing and fewer daytime and nighttime asthma symptoms, compared to those not taking the medication. The drug was also shown to be safe and effective for treating asthma in children as young as 12 years old.
ADHD and Girls

Zyflo Medication

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