Safety Concerns With Zyflo

Some Zyflo Warnings and Precautions

Following are some warnings and precautions to be aware of with Zyflo:
  • Zyflo can cause liver damage, which can result in liver failure or death. During treatment with Zyflo, you should let your healthcare provider know right away if you have signs of liver problems, such as:


    • Upper right abdominal pain (or stomach pain)
    • Nausea
    • Fatigue
    • Flu symptoms (such as a fever or chills)
    • Loss of appetite
    • Yellow eyes or skin
    • Dark urine.
Zyflo is not recommended for people who already have liver disease or for people who regularly drink large amounts of alcohol (which can also damage the liver).
  • Your healthcare provider should check your liver enzymes (using a simple blood test) before you start Zyflo and regularly while you are taking Zyflo, in order to detect any liver damage.
  • Zyflo is not a fast-acting asthma medication and cannot replace fast-acting rescue inhalers. Do not use Zyflo to treat an asthma attack. Everyone taking the medication for asthma should also have a rescue asthma medication available at all times. Let your healthcare provider know if you need to use your rescue inhaler more frequently than usual, as this may be a sign of worsening asthma.
  • Zyflo can interact with certain other medications (see Zyflo Drug Interactions).
  • Zyflo is considered a pregnancy Category C medication. This means that it may not be safe for use in pregnancy -- though the full risks are not known. Talk with your healthcare provider about the risks and benefits of using Zyflo during pregnancy (see Zyflo and Pregnancy for more information).
  • It is not known if Zyflo passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Zyflo (see Zyflo and Breastfeeding for more information).
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Zyflo Medication

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