Zyflo Drug Interactions

When medicines such as propranolol, warfarin, and theophylline are taken together with Zyflo, drug interactions can potentially occur. Drug interactions with Zyflo can raise the levels of some drugs in your blood and increase your risk for side effects or bleeding. You should make sure to talk with your pharmacist or healthcare provider about any Zyflo interactions that may apply to you.

 
In February 2008, the manufacturer of Zyflo announced that it has discontinued making this product. The manufacturer stated that since the longer-acting version, Zyflo CR, became available in 2007, use of immediate-release Zyflo declined significantly. Zyflo CR will still be available.
 

An Overview Zyflo Drug Interactions

Zyflo® (zileuton) can potentially interact with some other medicines. Some of these medicines that may lead to Zyflo interactions include:
 

Zyflo Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zyflo is combined with any of the drugs listed above.
 
Propranolol (Inderal, Inderal LA, InnoPran XL, Pronol)
Taking propranolol with Zyflo can raise the level of propranolol in your blood, increasing your risk of propranolol side effects. If you are taking propranolol along with Zyflo, your healthcare provider should monitor your heart rate and blood pressure, as well as decrease your propranolol dose if necessary.
(Zyflo Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;