Zyflo CR Warnings and Precautions

There are several Zyflo CR warnings and precautions to be aware of before taking the medication. For example, you should let your healthcare provider know if you have liver disease, as Zyflo CR can cause liver damage. Warnings and precautions also extend to people who have certain allergies and to women who are pregnant or breastfeeding.

Zyflo CR: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Zyflo CR™ (zileuton CR) if you have:
  • Liver disease, such as liver failure or cirrhosis
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Zyflo CR Warnings and Precautions

Some of the warnings and precautions to be aware of with Zyflo CR include the following:
  • Zyflo CR is not a fast-acting asthma medication and cannot replace fast-acting rescue inhalers. Do not use Zyflo CR to treat an asthma attack after it starts. Everyone taking Zyflo CR for asthma should also have a rescue asthma medication available at all times. Let your healthcare provider know if you need to use your rescue inhaler more often than normal, as this may be a sign that your asthma is getting worse.
  • Zyflo CR can cause liver damage, which can result in liver failure or death. Let your healthcare provider know right away if you have signs of liver problems, such as:
    • Upper right abdominal pain (stomach pain)
    • Nausea
    • Fatigue
    • Flu symptoms (such as fever or chills)
    • Loss of appetite
    • Yellowing of the whites of the eyes or skin
    • Dark urine.


Zyflo CR is not recommended for people who already have liver disease or for people who regularly drink large amounts of alcohol (which can also damage the liver).
  • Your healthcare provider should check your liver enzymes (using a simple blood test) before you start Zyflo CR and regularly while you are taking Zyflo CR, in order to detect any liver damage.
  • Zyflo CR can interact with other medications (see Zyflo CR Drug Interactions).
  • Zyflo CR is considered a pregnancy Category C medication. This means that Zyflo CR may not be safe for use in pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using Zyflo CR during pregnancy (see Zyflo CR and Pregnancy for more information).
  • It is not known if Zyflo CR passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Zyflo CR (see Zyflo CR and Breastfeeding for more information).
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