Drug Interactions With Zafirlukast
A few of the drugs that can potentially interact with zafirlukast include tolbutamide, carbamazepine, erythromycin, and aspirin. Drug interactions with zafirlukast can alter the levels of some medicines in your blood -- perhaps causing certain drugs to become less effective or increasing your risk of side effects. You should make sure to talk with your healthcare provider or pharmacist about any interactions with zafirlukast that may apply to you.
Zafirlukast (Accolate®) can potentially interact with some other medicines. Some of these medicines that may lead to interactions with zafirlukast include:
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®, Tegretol XR®)
- Clarithroymycin (Biaxin®, Biaxin XL®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Erythromycin (Ery-Tab®)
- Fluconazole (Diflucan®)
- Phenytoin (Dilantil®, Phenytek®)
- Theophylline (Theo-Dur®)
- Tolbutamide (Orinase®)
- Warfarin (Coumadin®, Jantoven®).
The following sections explain in detail the potentially negative interactions that can occur when zafirlukast is combined with any of the drugs listed above.
Taking zafirlukast with aspirin may raise the level of zafirlukast in your blood, possibly increasing your risk of side effects. Talk with your healthcare provider before taking aspirin with zafirlukast.