Specific Drugs That React With Zafirlukast

Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR)
Taking carbamazepine with zafirlukast can raise the level of carbamazepine in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor the level of carbamazepine in your blood -- especially when you are starting or stopping zafirlukast.
 
Clarithromycin (Biaxin, Biaxin XL)
Combining zafirlukast with clarithromycin may decrease the level of zafirlukast in your blood, perhaps making it less effective. Be sure to let your healthcare provider know if your asthma symptoms worsen while you take clarithromycin.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Taking cyclosporine with zafirlukast can raise the level of cyclosporine in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor the level of cyclosporine in your blood -- especially when you are starting or stopping zafirlukast.
 
Erythromycin (Ery-Tab)
Combining zafirlukast with erythromycin may decrease the level of zafirlukast in your blood, perhaps making it less effective. Be sure to let your healthcare provider know if your asthma symptoms worsen while you take erythromycin.
 
Fluconazole (Diflucan)
Fluconazole may increase the level of zafirlukast in the blood. It is unknown how significant this interaction may be. Check with your doctor before taking these medications together.
 
Phenytoin (Dilantin, Phenytek)
Taking phenytoin with zafirlukast can raise the level of phenytoin in your blood, perhaps increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor the level of phenytoin in your blood -- especially when you are starting or stopping zafirlukast.
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