Drugs That Interfere With Salmeterol

Interactions With Salmeterol Explained

The following sections explain in detail the potentially negative interactions that can occur when salmeterol is combined with any of the drugs listed above.
Beta Blockers
Taking salmeterol and a beta blocker together can decrease the effectiveness of both medications. Additionally, people with asthma should generally avoid beta blockers, as they may worsen their condition. While some beta blockers are less likely than others to interact with salmeterol, all beta blockers can potentially cause problems.
Certain Antibiotics or Antifungals
Taking salmeterol with certain antibiotics or antifungals can raise the level of salmeterol in your blood, increasing your risk of serious side effects. Be sure to talk with your healthcare provider before taking salmeterol with certain antibiotics or antifungal medications. 
Certain Diuretics
Taking salmeterol and certain diuretics together can increase your risk of low potassium levels (hypokalemia), especially when you use salmeterol more frequently than recommended. Talk with your healthcare provider before using these medications together.
Digoxin (Digitek, Lanoxin)
Salmeterol may decrease the level of digoxin in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to monitor the level of digoxin in your blood and adjust your digoxin dosage as necessary -- especially when you are starting or stopping salmeterol.
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