Pycnogenol^® -- a "natural" product used in various dietary supplements -- is claimed to help with conditions ranging from chronic venous insufficiency to asthma. It is made from the bark of French maritime pine trees, but should not be confused with other sources of pycnogenols. The supplement supposedly offers several health benefits, such as antioxidant and anti-inflammatory effects, as well as stimulating the immune system. Side effects of Pycnogenol may include headaches, nausea, and dizziness.