Drug Interactions With Montelukast

If certain medications are taken together, there is a possibility of negative drug interactions. With montelukast, these interactions can decrease the level of montelukast in your system, which may decrease the drug's effectiveness. Drug interactions with montelukast can occur if it is combined with rifamycin antibiotics or some anticonvulsants. Your healthcare provider may adjust your dosages to prevent these interactions from occurring.

Drug Interactions With Montelukast: An Introduction

Montelukast sodium (Singulair®) can potentially interact with other medications. Some of the medicines that may lead to drug interactions with montelukast include:
 
 
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®).
     

More Information on Interactions With Montelukast

The following sections explain in detail the potentially negative interactions that can occur when montelukast is combined with any of the drugs listed above.
 
Certain Anticonvulsants
Some anticonvulsants can decrease the level of montelukast in your blood, perhaps making it less effective. Although the manufacturer of montelukast does not recommended adjusting the montelukast dosage due to this drug interaction, let your healthcare provider know if your allergy or asthma symptoms seem to become worse while taking anticonvulsant medications.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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