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Drug Interactions With Metaproterenol
Drug interactions with metaproterenol may occur with a variety of medications. Some of the medicines that can potentially interact with metaproterenol include beta blockers, certain diuretics, MAOIs, and tricyclic antidepressants. Some of these potential drug interactions with metaproterenol can cause side effects, such as low potassium levels, an irregular heart rhythm, or dangerously low blood pressure.
An Overview of Drug Interactions With Metaproterenol
Metaproterenol is no longer available in the United States. The manufacturer of this medication decided to stop making it in order to comply with regulations concerning chlorofluorocarbons (CFCs), chemicals that may deplete the ozone layer. The product was rarely used anymore; had it been more popular, the manufacturer probably would have chosen to reformulate it without CFCs, instead of just discontinuing it.
Metaproterenol sulfate (Alupent®) can potentially interact with a few other medicines. Some of these medicines that may lead to metaproterenol interactions include:
- Beta blockers, such as:
- Atenolol (Tenormin®)
- Bisoprolol (Zebeta®)
- Metoprolol (Lopressor®, Toprol-XL®)
- Nadolol (Corgard®)
- Propranolol (Inderal®)
- Sotalol (Betapace®)
- Timolol (Blocadren®)
- Carvedilol (Coreg®)
- Labetalol (Trandate®)
- Certain diuretics, such as:
- Bumetanide (Bumex®)
- Chlorothiazide (Diuril®)
- Chlorthalidone (Thalitone®)
- Ethacrynic acid (Edecrin®)
- Furosemide (Lasix®)
- Hydrochlorothiazide (Esidrix®, HydroDIURIL®, Microzide®, Oretic®)
- Metolazone (Zaroxolyn®)
- Torsemide (Demadex®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Tricyclic antidepressants, including:
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD



